Thursday, January 5, 2012

Brown?s University an education in beer

TROY ? Brown?s Brewing is going Ivy League, sort of. ?Brown?s University Beer 101,? a symposium on all things beer, is scheduled for the brewer?s Revolution Hall event space next Wednesday, January 11.

Brown?s is billing the event as ?Everything (almost*) that you wanted to know about beer. ? (A) fun entry level practicum for the beer novice.?

The 6 p.m. symposium will include:

? The Anatomy of Beer: A discussion on the ingredients of beer and the differences between lagers and ales. The student will taste and smell the raw ingredients of beer and gain an understanding of how they distinguish the many different beer styles.

? The Brewing Process: An overview of how beer becomes beer, from grain to glass.

? The History of Beer: The ancient origins of beer and how it has evolved, devolved and evolved again.

? The Business of Beer: A discussion of how the wholesale beer trade works.

? Beer Tasting: A sampling of Brown?s ales and lagers.

Admission, which includes samples and snack, is $45 per person, $40 for Mug Club members. Tickets are available at Brown?s host desk or online.


Get all the latest news on my Upstate Restaurant Examiner column and check out what?s coming up on my NY Drinks Events Calendar.

Source: http://blog.timesunion.com/dowdondrinks/browns-university-an-education-in-beer/10644/

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Monday, January 2, 2012

Triple Analysis: Pancreatic Cancer, Prostate Cancer and Apoptosis

This triple analysis focuses on cancer drug development strategies in both Pancreatic Cancer and Prostate Cancer and by the mechanism/target/effect of Apoptosis. Each of these three individual parts is evaluated according to standardized criteria in a five pillar pipeline drug assessment methodology to compare drug development strategies in oncology. This makes it easy to find and compare analysis not only within one single cancer focus area but also between different areas.

Below is a short synopsis of each part included in this report:

Part I: Pancreatic Cancer

The pancreatic cancer report part comprises defined and up to date development strategies for 213 pancreatic cancer drugs within the portfolio of 137 investigators, from Ceased to Marketed. This report part extensively analyses 171 identified targets of pancreatic cancer drugs, organized into 142 drug target profiles, and assesses them in pancreatic cancer.

This part is based on the following publication:

Portfolio Analytics in the Pancreatic Cancer Pipeline and Portfolio Planning - High Unmet Medical Need but Where to Target?

Part II: Prostate Cancer

The prostate cancer report part comprises defined and up to date development strategies for 346 prostate cancer drugs within the portfolio of 198 investigators, from Ceased to Marketed. This report part extensively analyses 202 identified targets of prostate cancer drugs, organized into 187 drug target strategies, and assesses them in prostate cancer.

This part is based on the following publication:

A Decision Support Tool for Optimizing the Prostate Cancer Pipeline: From Research and Development to Market

Part III: Apoptosis

The apoptotic cancer drug report part comprises defined and up to date development strategies for 234 drugs in oncology within the portfolio of 158 companies world-wide, from Ceased to Marketed. The report extensively analyses their 181 identified drug targets, organized into 157 drug target strategies, and assesses them in 69 cancer indications.

This part is based on the following publication:

Commercializing Apoptotic Drugs in Cancer: The Faster Route to Consider Your Options and Position of Others

The report is written for you to understand and assess the impact of competitor entry and corresponding changes to development strategies for your own portfolio products. It helps teams to maximize molecule value by selecting optimal development plans and manage risk and uncertainty. The report serves as an external commercial advocate for pharmaceutical companies? pipeline and portfolio planning (PPP) in cancer by:

  • Providing you with competitive input to the R&D organization to guide development of early product ideas and ensure efforts are aligned with business objectives
  • Assisting you to make informed decisions in selecting cancer indications that are known to be appropriate for your drug?s properties
  • Analyzing, correlating and integrating valuable data sources in order to provide accurate data for valuation of pipeline, in-licensing and new business opportunities
  • Providing you with commercial analytic support for due diligence on in-licensing and acquisition opportunities
  • Supporting development of integrative molecule, pathway and disease area strategies
  • Integrating knowledge for you to consider the therapeutic target for the highest therapeutic outcome and return on investment
This report provides systems, analytical and strategic support both internally to PPP and to stakeholders across your own organization. The report will also be an important part of creating and implementing a market development plan for cancer drugs to insure that the optimal market conditions exist by the time the products are commercialized.

Source: http://c.moreover.com/click/here.pl?r5684239807&f=378

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Top 10 local sports stories of 2011: Pack football takes top spots

Top 10 local sports stories

1. Kaepernick caps historic career; Pack has three NFL draft picks
2. Wolf Pack wins Kraft Fight Hunger Bowl
3. Aces win division, make playoffs
4. Truckee goes undefeated for third straight year
5. Nevada basketball suffers rare losing season
6. Manogue boys basketball wins Northern 4A, beats Bishop Gorman
7. RTO switches nines, Nevadan wins 13th annual PGA Tour event
8. Reno Bighorns advance to playoffs
9. Freshman Fajardo leads Pack to bowl game
10. Wolf Pack women win WNIT game

Source: http://www.rgj.com/article/20111231/SPORTS/112310314/1018

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Sunday, January 1, 2012

Curry, No. 7 Duke rout Western Michigan 110-70 (AP)

DURHAM, N.C. ? Seth Curry scored a season-high 22 points, Austin Rivers added 20 and No. 7 Duke routed Western Michigan 110-70 on Friday night.

Quinn Cook had 16 points and Josh Hairston finished with 13, helping the Blue Devils (11-1) win their fourth straight. They shot 54 percent, held a 50-28 rebounding advantage and used a huge early run and a knack for getting to the free-throw line to take a 30-point lead in the first half.

Duke hit triple digits for the first time this season after scoring 63 points by halftime, its most in a half since its 66-point second half last year against Colgate.

Matt Stainbrook had 18 points to lead the Broncos (5-8). They had their four-game winning streak snapped in decisive fashion and were beaten by an Atlantic Coast Conference team for the first time in program history.

Miles Plumlee had a career-high 15 rebounds and Tyler Thornton added 12 points for the Blue Devils, who faced little resistance in extending a few impressive streaks at Cameron Indoor Stadium.

They won their 42nd in a row at home ? only the 46-game winning streak from 1997-2000 was longer at the venerable arena ? and claimed its 92nd straight victory at Cameron against non-ACC teams.

Curry wound up having one of his best days in a Duke uniform, matching the 22 points he scored in last year's home victory over North Carolina. He finished shy of the career-best 35 points he scored against VMI as a freshman at Liberty three years ago before transferring to Duke.

The Blue Devils were playing for just the second time in nearly three weeks ? because of final exams and the holiday break ? and first time since a 27-point romp against UNC Greensboro on Dec. 19. The pace picks up in a hurry: They have fewer than 48 hours to prepare for Sunday afternoon's game against Pennsylvania.

That long layoff certainly had no effect on them in this one.

The Blue Devils took command with an early 32-6 run in which they did some of the things they do best ? find ways to get to the line, and lock down on defense.

Duke had 16 free throws ? making 13 of those ? before Western Michigan even attempted its first foul shot, and by that point the Blue Devils had pushed their lead well into the 20s for good. Before the first half ended, the Broncos had five players with three fouls apiece.

Plumlee started the decisive run with a three-point play, Austin scored six points during the burst, Hairston put Duke up 20 with a free throw with 10 1/2 minutes left in the half and freshman Michael Gbinije capped the burst with a 3-pointer from the right wing to make it 32-8 with 8:45 left before the break.

The Blue Devils held the Broncos without a field goal for more than 6 minutes, came away with points on 14 consecutive trips downcourt and eventually went up 30 when Curry's free throw with 6.5 seconds before halftime pushed it to 63-33.

Demetrius Ward added 16 points and Hayden Hoerdemann finished with 12 for Western Michigan, which entered 6-0 against current ACC teams but was denied in its bid to become the second Mid-American Conference school to beat a Mike Krzyzewski-coached Duke team.

Source: http://us.rd.yahoo.com/dailynews/rss/sports/*http%3A//news.yahoo.com/s/ap/20111231/ap_on_sp_co_ga_su/bkc_t25_wmichigan_duke

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Thursday, December 29, 2011

iHaz3: RT @the52eighty: @iHaz3 okay. Okay. Will do. Wheeew thought i messed up. I mean without Aftermath i am lost like a blonde without Facebook

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@iHaz3 okay. Okay. Will do. Wheeew thought i messed up. I mean without Aftermath i am lost like a blonde without Facebook the52eighty

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Source: http://twitter.com/iHaz3/statuses/152132667935166464

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Wednesday, December 28, 2011

This rotating dome home spins right 'round

Zillow

The dome home rotates to take advantage of the sun's energy.

By Erika Riggs, Zillow

116 Canaan Rd, New Paltz NY
For sale: $1,200,000

Normally, when someone asks for the remote, it's because they want to undertake some serious TV channel surfing. But in one unique home located just 90 minutes north of New York City, playing with the remote control will set the entire wooden house spinning on its axis.

This dome home was, in fact, built on an electronically-controlled axle. So with a push of a button, the 3,000-square-foot New Paltz home for sale can rotate 360 degrees. In five orbital minutes, the house completes one full rotation.

The owners of this circular domicile aren't constantly on the spin cycle. The feature is used to take advantage of the sun for the home's solar energy needs. Each season, the home is rotated for maximum efficiency, explained listing agent Anne Rajs.

While the home looks similar to geodesic dome homes, it was built using a kit from France called Domespace and is the only structure like it that has been constructed in the U.S.

"It does look like a space ship," said Rajs, "But it's an amazing home. It's the coolest home I've ever seen."

The two-story home features 40-foot ceilings centered by the axle. Tall, wedge-shaped windows keep the interiors light-filled and open. The home features bamboo flooring and custom wood and stone cabinetry. The first floor contains two bedrooms and the majority of the living space. A central spiral staircase leads to the second floor which holds the master suite, office and additional balcony space.

Although one of the home's main appeals is its unique design, Rajs believes that the home's location is a big sell as well.

"It's this beauty of a house in the middle of 28 acres," Rajs said. "And you can walk to the Mohonk Preserve which has 1,000 acres more of hiking and rock climbing."

The home has also been featured on the Discovery Channel and a video of the interiors, as well as the home rotating, is on YouTube.

According to Zillow's mortgage calculator, a monthly mortgage payment on the home will be $4,475, assuming a 20 percent down payment on a 30-year-fixed-rate mortgage.

?

Zillow

The axel stretches to the home's ceiling.

Zillow

The home has several tall arching windows to take advantage of the natural light.

Source: http://bottomline.msnbc.msn.com/_news/2011/12/27/9640989-listing-of-the-week-this-rotating-dome-home-spins-right-round

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Bigfoot sparks curiosity in Texas, worldwide

Bigfoot. Sasquatch. Skunk Ape. Yowie. Yeti. Abominable Snowman. In Texas you may have heard of the Caddo Creature, the Lake Worth Monster/Goat-Man or the Liberty County Monkey Man.

There are many names for the hairy humanlike creature that walks on two legs and has eluded searchers for decades. Even Animal Planet's Finding Bigfoot series has been unable to find the ape-man typically described as being 6 to 8 feet tall, with a massive, bulky build.

The Finding Bigfoot crew has not visited Texas yet, but something is out there deep in the Big Thicket, say members of Texas groups dedicated to hunting the beast.

Ken Gerhard of the Gulf Coast Bigfoot Research Organization has never seen one, but he thinks technology will help solve the mystery.

"I have been immersed in Sasquatch research for a number of years, and I can tell you in my mind a mountain of evidence supports the existence of these creatures," Gerhard said. When hunting season ends, he will return to the woods to look for tracks, hair and habitations and to listen for vocalizations at night.

There have been sightings along the Trinity River corridor, and a cast of a suspected Bigfoot track was made in Sam Houston National Forest, said Gerhard, a San Antonio cryptozoologist who co-wrote Monsters of Texas (CFZ, $16.99) with Nick Redfern.

Texas is in the top 10 states for Bigfoot sightings, Gerhard said, outranked only by Washington, California, Oregon, Ohio and Florida.

"Eventually someone is going to come up with some evidence, although it is very frustrating that we have not found a body yet," he said. "And it is a very good argument against Bigfoot's existence."

Exactly, said Mike Cox, a spokesman for the Texas Parks and Wildlife Department, which discounts the idea of Bigfoot running around the woods. Someone would have found some verifiable piece of evidence by now, TPWD biologists contend.

"The theory is that with as much traffic as there is in East Texas that sooner or later a Bigfoot would not stop, look and listen and make the mistake of walking out into traffic and become the victim of a hit-and-run," Cox said. Or a hunter would mistakenly shoot one.

Texas has 180 known mammals ranging from bats to white tail deer, Cox said. Bigfoot is lumped with the cryptids, legendary creatures.

Bigfoot makes TPWD's top 3 cryptid list. The department gets more calls about chupacabra, which biologists think are mangy coyotes, Cox said. Bigfoot, which they call pure folklore, ranks No. 2. Then there are sightings of lechuzas, usually along the border and generally thought to be swooping owls in the night sky, not swooping witches.

As a student of Texas history and mythology and a hunter, Cox appreciates the intrigue of the Bigfoot story.

"I've been out in some pretty desolate places in the pursuit of game, so it has crossed my mind: What would I do if I was sitting up in a deer blind and ?waiting to see a big buck come out of the brush and instead I saw another creature come out. But it hasn't happened yet to me," he said. "It's fun to imagine what might be there."

Biological sciences professor Jeffrey Meldrum of Idaho State University is convinced Sasquatch is not a myth.

Meldrum, who dislikes the tabloid connotations of the name Bigfoot, studies primate comparative anatomy, especially footprint evidence. From tracks he has analyzed, Meldrum leans toward the hypothesis that Sasquatch is a species of large ape. Yet the creature does not exhibit evidence of material culture or use of tools, fire or home bases.

The author of Sasquatch: Legend Meets Science (Forge Books, $16.99) says the popularity of the Finding Bigfoot TV series makes researchers more skeptical of Bigfoot reports.

"You have to be careful. I have been out with people for whom every overturned rock, every bent twig, every bump in the night is attributed to Bigfoot," he said.

Vaughn M. Bryant, professor of anthropology at Texas A&M University, became involved in Bigfoot research in the early 1970s at Washington State University, an area where Bigfoot is a tourist attraction.

Although he is open to possibilities, Bryant says he can't be a Bigfoot believer without physical evidence. "Photos and footprints are not enough. They can and have been faked fairly effectively," Bryant said.

His specialty is paleo nutrition and the study of coprolites, or fossilized feces.

"Quite frankly, I have tried to get out of the Bigfoot-poop business because it is very time consuming and didn't really lead anywhere productive," Bryant said. At A&M he is studying excrement found in the Paisley Caves of Oregon that is 12,000 years or older.

Plus, he noted, most universities don't encourage their professors to publicly ponder Sasquatch.

"If you are in academia, if you start talking about Bigfoot, people start to wonder: Has this guy lost his mind or what?" Bryant said.

Lyle Blackburn, a member of the Texas Bigfoot Research Conservancy, has heard snickers when he is asked: "Do you believe in Bigfoot?"

It is a question that provokes the author of the upcoming The Beast of Boggy Creek: True Story of the Fouke Monster "Belief implies some sort of faith. Either the animal exists or it doesn't. There's no faith to it," Blackburn said.

The Bedford resident described Bigfoot as one of the larger mysteries of the world. "The point is, I like camping and I like hunting and I like mysteries, and it sort of combines all that," he said.

"It's not about the end goal always. It's about meeting people, having fun and hearing some really cool stories. So if you look at it that way, it's an interesting subject, and if turns out to be true, all the better."

?

lana.berkowitz@chron.com

Source: http://feeds.chron.com/~r/houstonchronicle/topheadlines/~3/P-KmKnbIiZ8/Searching-for-Bigfoot-in-Texas-2425856.php

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